Diclofenac Sodium IP 25 mg


Diclofenac Sodium belongs to a group of drugs called non-steroidal anti-inflammatory drugs or NSAIDs. It is usually used to relieve pain, inflammation and fever.


⇒ Sprains, strains and other injuries
⇒ Pain and inflammation following surgery
⇒ Rheumatic pain
⇒ Muscular pain
⇒ Osteoarthritis
⇒ Rheumatoid arthritis
⇒ Ankylosing spondylitis
⇒ Acute gout
⇒ Backache
⇒ Pain relief in fractures
⇒ Dental pain
⇒ Period pain
⇒ Fever
⇒ Migraine


Diclofenac is an acetic acid nonsteroidal antiinflammatory drug (NSAID) with analgesic and antipyretic properties. Diclofenac is used to treat pain, dysmenorrhea, ocular inflammation, osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and actinic keratosis. The anti-inflammatory effects of diclofenac are believed to be due to inhibition of both leukocyte migration and the enzyme cylooxygenase (COX-1 and COX-2), leading to the peripheral inhibition of prostaglandin synthesis. As prostaglandins sensitize pain receptors, inhibition of their synthesis is responsible for the analgesic effects of diclofenac.


Absorption:- Well absorbed following oral administration .
Distribution:- widely distributed in animals.Plasma protein binding exhibited is >99%.
Elimination:- hepatic metabolism leads to elimination through urine.

Adverse Effects

⇒ Feeling Sick (Nausea).
⇒ Ulcers of the stomach or bleeding and Worsening of existing bowel conditions (ulcerative colitis, Crohn's disease).
⇒ Blood disorders (including anaemia and being prone to minor infections and bleeding).
⇒ Skin problems (including hives, itching, rash, irritation).
⇒ Headache.
⇒ Dizziness.
⇒ Gastritis (inflammation of the stomach).
⇒ Fluid retention (swollen ankles is one of the symptoms).
⇒ Ringing in the ears.
⇒ Diarrhoea.
⇒ Pancreatitis (inflammation of the pancreas, a gland located behind the stomach that plays a role in digestion).

Drug Interactions

This Drug Should not be Used with the Following Medications because very Serious, Possibly Fatal Interactions may occur:
⇒ Blood thinning drugs such as warfarin and phenindione.
⇒ Ciclosporin
⇒ Methotrexate
⇒ Other non-steroidal anti-inflammatory pain-killer drugs (NSAIDs).
⇒ Lithium
⇒ Quinolones (used to treat infection e.g. ciprofloxacin and levofloxacin).
⇒ Aspirin .

Over Dosage

Symptoms of overdose include headache, nausea, sickness (vomiting), stomach pain, diarrhoea, drowsiness, coma, tinnitus (ringing or buzzing noise in the ears), fainting and fits.