FERIVAR Capsule

FERIVAR

PRESENTATION:
Ferrous Ascorbate
Folic Acid

PACKING AVAILABLE:
(1X10) (ALU-ALU)
Ferrous Ascorbate & Folic Acid Capsule, ensures superior absorbtion & better bioavailability.Ferrous Ascorbate & Folic Acid,has additional Anti oxidant properties which ensures maximum iron utilisation. Ferrous ascorbate folic acid is a vital vitamin that helps a pregnant woman attains a good health during the entire pregnancy. A pregnant woman is likely to become anemic during the entire stage of conception and taking a ferrous ascorbate folic acid regularly or on a daily basis would provide a pregnant woman the sufficient amount of iron and folic acid

Indication and Usage



⇒It has better tolerability in GIT
⇒Indicated in spina bifida
⇒Indicated in pregnancy
⇒Indicated in post operative traumatic injuries
⇒Indicated in Menorrhagia
⇒Indicated in Lactation
⇒Indicated in Blood loss
⇒Reduces cost of therapy
⇒Ensures maximum iron utilisation
⇒Additional Anti oxidant properties
⇒Ensures superior absorbtion & better bioavailability

Folic Acid



Folic Acid (also known as vitamin B9, vitamin Bc or folacin) and folate (the form naturally occurring in the body), as well as pteroyl-L-glutamic acid, pteroyl-L-glutamate, and pteroylmonoglutamic acid are forms of the water-soluble vitamin B9.Folic acid is used for preventing and treating low blood levels of folic acid (folic acid deficiency), as well as its complications, including "tired blood" (anemia) and the inability of the bowel to absorb nutrients properly. Folic acid is also used for other conditions commonly associated with folic acid deficiency, including ulcerative colitis, liver disease, alcoholism, and kidney dialysis.

Drug Interactions



Ferrous Ascorbate:-

Decreased absorption of both iron and the concomitantly administered drugs: Tetracycline, Penicillamine, Methyldopa, Levodopa, Bisphosphonates, Quinolones and calcium. An interval of 2-3h between the iron intake and that of the above drugs is advised.

Folic Acid:-

Folic Acid Loss: Renal dialysis, concomitant administration of anticonvulsants-(diphenylhydantoin, primidone, and barbiturates), pyrimethamine and nitrofurantoin, antibiotics Tetracycline). Decreased vitamin B12 serum levels may occur in patients receiving prolonged Folic Acid therapy.

Pharmacology



Ferrous Ascorbate is a synthetic molecule of ascorbic acid and iron. Iron is critical to a number of synthetic and enzymatic processes. Most of the body iron is part of the hemoglobin molecule where iron serves a key role in oxygen transport. Small amounts of iron are found in myoglobin and in plasma (bound to transferrin ). Iron is recycled and thus conserved bythe body. Folic Acid. Folic Acid acts on megaloblastic bone marrow to produce a normoblastic marrow. Exogenous source of folate is required for nucleoprotein synthesis and the maintenance of normal erythropoiesis. Folic Acid is the precursor of tetrahydro Folic Acid, which is involved as a cofactor for transformylation reactions in the biosynthesis of purines and thymidylates of nucleic acids. Impairment of thymidylate synthesis in patients with Folic Acid deficiency is thought to account for the defective deoxyribonucleic acid (DNA) synthesis that leads to megaloblast formation and megaloblastic and macrocytic anemias.

Pharmacokinetics Actions



Ferrous Ascorbate:-

Absorption:- Iron absorption occurs predominantly in the duodenum and upper je junum
Distribution:- 90% of iron is boundto protein.
Metabolism:- Iron binds to transferrin and istransported to the spleen, bone marrow and liver, which are the main storage sites for enclogenous iron.
Elimination:- Because absorption is low and because iron is recycled in the body, less than 1 mg/d of endogenous iron is lostbythe skin, faeces and urine.

Folic Acid:-

Absorption:- Folic Acid is absorbed rapidly from the small intestine, primarily from the proximal portion.
Distribution:- Folic Acid appears in the plasma approximately 1 5 to 30 minutes after an oral dose; peak levels are generally reached within 1 hour. TetrahydroFolic Acid derivatives are distributed to all body tissues but are stored primarily in the liver
Metabolism:- F olic Acid is metabolized in the liver to 7, 8- dihydroFolic Acid and eventually to 5, 6, 7, 8-tetrahydroFolic Acid with the aid of reduced diphosphopyridine nucleotide (DPNH) and folate reductases.
Elimination:- 90% of Foloic Acid is excreted through urine and a small amount through the feaces.

Contraindication



Ferrous Ascorbate is contraindicated in patients with hypersensitivityto Iron Iron supplementation (which circumvents this mechanism) should be avoided in patients who have active bacterial infections Contraindicated in patients with Hemosiderosis, Hemochromatosis, Hemolytic anemia.

Storage



Store in cool and dry place.