ZIMZOL-PLUS Tablet

ZIMZOL-PLUS

PRESENTATION:
Albendazole IP 400 mg
Ivermectin IP 6 mg

PACKING AVAILABLE:
(30X1) (BLISTER)
Before knowing its combination , first we should need to know how they work individually and we know that Ivermectin is a broad-spectrum antiparasitic medicine and effective against worm infestations (such as strongyloidiasis, ascariasis, trichuriasis, filariasis, enterobiasis and Albendazole is used as a drug indicated for the treatment of a variety of worm infestations. It is a broad spectrum anthelmintic, effective against roundworms, tapeworms, and flukes of humans.
It has been demonstrated by recent studies concomitant administration of Ivermectin and Albendazole suspension, shows better symptoms relief compared with modest improvement of onchocerciasis some worm infestations like ascariasis, trichuriasis, filariasis. It is also effective against Flatworms, Flukes, Fasciolosis, Tapeworm, Cysticercosis, Echinococcosis and Hook worms.

Indications and Usage



⇒ It is traditionally used against worms.
⇒ It is mainly used in humans in the treatment of onchocerciasis, but is also effective against other worm infestations (such as strongyloidiasis, ascariasis, trichuriasis, filariasis, enterobiasis, and some epidermal parasitic skin diseases, including scabies .
⇒ It is effective against Flatworms, Flukes, Fasciolosis, Tapeworm, Cysticercosis, Echinococcosis, Nematodes, Enterobiasis, Trichuriasis Ascariasis and Hookworm.

Pharmacodynamics



Ivermectin and other avermectins (insecticides most frequently used in home-use ant baits) are macrocyclic lactones derived from the bacterium Streptomyces avermitilis. Ivermectin kills by interfering with nervous system and muscle function, in particular by enhancing inhibitory neurotransmission. The drug binds and activates glutamate-gated chloride channels (GluCls). GluCls are invertebrate-specific members of the Cys-loop family of ligand-gated ion channels present in neurons and myocytes. After albendazole(ABZ) is administered, intestinal and hepatic albendazole metabolism leads to albendazole sulfoxide (active metabolite) and albendazole sulfone (inactive metabolite) formation. The metabolism albendazole sulfoxide effects as the active substance against the worms, albendazole sulfone has no active affection. Therefore albendazole sulfoxide anthelmintic function is better than albendazole.

Pharmacokinetics



Ivermectin can be given either by mouth or injection. It does not readily cross the blood–brain barrier of mammals due to the presence of P-glycoprotein, although crossing may still become significant if it is given at high doses (in which case, brain levels peak 2–5 hr after administration). In contrast to mammals, ivermectin can cross the blood–brain barrier in tortoises, often with fatal consequences.

Absorption:- Albendazole is poorly absorbed from the GI tract; however, it is rapidly converted to its primary active metabolite, albendazole sulfoxide, prior to reaching systemic circulation. Fatty meals enhance bioavailability, as indicated by up to a 5-fold increase in plasma concentration in albendazole sulfoxide. Albendazole sulfoxide plasma concentrations are dose-dependent. C max is achieved in 2 to 5 h and ranges from 0.46 to 1.58 mcg/mL, when given with a fatty meal.
Distribution:- Albendazole sulfoxide is 70% protein bound and widely distributed throughout the body.
Metabolism:- After metabolism in the liver to albendazole sulfoxide, it is further metabolized to albendazole sulfone and other oxidative metabolites.
Elimination:- Albendazole sulfoxide elimination half-life is 8 to 12 h. Biliary elimination of albendazole sulfoxide results in biliary concentrations similar to plasma concentration. Urinary excretion is a minor elimination pathway (less than 1%).

Mechanism of Action



We are using combination of Ivermectin and Albendazole suspension and from mode of action we come to know that how it effective in our body so Ivermectin kills the larval Onchocerca volvulus worms microfilariae that live in the subcutaneous tissue of an infected person. It is believed to paralyse or kill the microfilariae gradually, so avoiding the intense inflammatory responses induced when they die naturally. Treatment with ivermectin relieves intense skin itching and halts the progression towards blindness. Albendazole causes degenerative alterations in the tegument and intestinal cells of the worm by binding to the colchicine-sensitive site of tubulin, thus inhibiting its polymerization or assembly into microtubules. The loss of the cytoplasmic microtubules leads to impaired uptake of glucose by the larval and adult stages of the susceptible parasites, and depletes their glycogen stores. Degenerative changes in the endoplasmic reticulum, the mitochondria of the germinal layer, and the subsequent release of lysosomes result in decreased production of adenosine triphosphate (ATP), which is the energy required for the survival of the helminth. Due to diminished energy production, the parasite is immobilized and eventually dies.

Side Effects



⇒ Abdominal pain
⇒ Dizziness
⇒ Headache
⇒ Nausea
⇒ vomiting

Contraindications



contraindicated in persons with a history of hypersensitivity.

Conclusions



From the above discussion, it can be concluded that this Ivermectin and Albendazole suspension could improve the quality of life with onchocerciasis and some worm infestations like ascariasis, trichuriasis, filariasis. It is also effective against Flatworms, Flukes, Fasciolosis, Tapeworm, Cysticercosis, Echinococcosis and Hook worms.
We are making superior quality Ivermectin and Albendazole suspension that is used to treat a variety of worm infestations (such as strongyloidiasis, ascariasis, trichuriasis, filariasis, enterobiasis, and some epidermal parasitic skin diseases, including scabies and effective against Hook worms Flatworms. Our offered suspension is processed using high grade chemical compounds and other required drugs by our experienced quality controllers that ensure its quality, purity and chemical properties. Highly treasured among the clients for its reliability, accurate composition, excellent physical and purity, this suspension is offered to our esteemed clients at the market leading prices.

Storage



⇒ Store in cool and dry place.
⇒ Protect from heat and light.